Layers can record position offsets and painting, it can be useful for non-linear workflow. For example by experimenting different facial expression without relying on the history stack to undo the changes.
For painting data, layers are sorted in a top-down fashion; so layers on top will mask the lower ones. The order only matter for the painting information, the sculpting part (offset) isn't impacted.
You can clear part of this mask by using the Delete Layer tool.
|Visible||Show/hide the layer influence|
|Edit Name||Edit the layer name|
|Delete||Delete the layer|
|Move||Hold to move the layer position in the list|
|Duplicate||Duplicate the layer|
|Merge Down||Merge the layer with the lower layer (or base mesh)|
If you want more control you can change the intensity of each channel of a layer:
Unlike many sculpting softwares, changing the topology of a mesh will not discard the layers.
However for the Voxel Remesher, the quality of the layer will be impacted.